NGS applications
Beyond monogenic diseases and tumor classification
Exercises
Exercise 1: liquid biopsy
- circulating tumor DNA - Wikipedia
- CancerSEEK editorial, article
Exercise 2: blood-free liquid biopsy
Exercise 3: NGS in prenatal diagnostics
- Cell free fetal DNA
- Non-invasive whole genome sequencing of a human fetus
- Fetal cells in the mother's blood
- Fetal Cells Offer Promise in Prenatal Testing
Exercise 4: NGS in newborn screening
- What is the purpose of newborn screening?
- How is newborn screening done?
- Which conditions are typically screened for?
- What is the technology currently used for the newborn screening?
- Direct-to-consumer newborn WGS
Exercise 5: Single cell sequencing
- Medical applications of single-cell sequencing in cancer sections 'Introduction' and 'Investigating tumor heterogeneity with SNS'
- If there are some undefined or unclear terms you can look them up on the Wikipedia page, but you don't have have to discuss the content of this resource in your presentation.
- The first paper is quite clear, but rather old. If you have time take a peek at the progress reported 10 years later, section 'Applications of single-cell sequencing in cancer biology'